• Apoptosis in Neurobiology

    Apoptosis in Neurobiology - CRC Press Book Название: Apoptosis in Neurobiology
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    Apoptosis in Neurobiology - CRC Press Book
    Apoptosis in Neurobiology is an important resource for researchers in this emerging frontier of biomedical study. This volume allows the uninitiated ...

    Apoptosis in Neurobiology

    Similar changes have been reported in neurons in the presence of oxidative stress. However, contemporary neurobiologists typically rely on cell culture models for studying neuronal apoptosis, and these models are rarely validated ultrastructurally rather they are assumed to be appropriate models based on unvalidated biochemical tests for apoptosis. .

    In the absence of such criteria, the kerrwyllie description pertaining to nonneuronal cells has served as a reference standard. We have performed an ultrastructural analysis of the neuronal cell death process triggered in the cerebral cortex and thalamus by these several methods and compared it with physiological cell death (pcd), a prototypic example of neuronal apoptosis that occurs naturally in the developing brain. This confirms that each of these methods produces apoptotic neurodegeneration, and it signifies that our description of this neuronal apoptotic process, which differs in some respects from the kerrwyllie description of nonneuronal apoptosis, can serve as a useful reference standard for recognizing the characteristic changes that check if you have access through your login credentials or your institution.

    In the current study, hyperglycemia induces apoptotic changes in dorsal root ganglion neurons and schwann cells both in streptozotocin-treated diabetic rats and in rats made acutely hyperglycemic with infused glucose. These changes are coupled with activation of caspase-3, dependent on the concentration of glucose. We suggest that oxidative stress may promote the mitochondrial changes in diabetic animals and lead to activation of programmed cell death caspase pathways.

    Typical apoptotic nuclear and cytoplasmic changes are observed. Whether the cell death process in neurodegenerative diseases meets ultrastructural criteria for apoptosis has been given very little consideration. Recently, several methods have been described for triggering extensive apoptotic neurodegeneration in the developing mammalian brain.

    There are very few studies providing detailed ultrastructural criteria for recognizing neuronal apoptosis in the mammalian brain. These methods include head trauma or treatment with several types of drugs (nmda antagonists, gaba agonists, or ethanol). Relying on evidence generated in such cell culture models or on nonspecific cytochemical tests applied to brain tissue, many authors have recently suggested that an apoptotic mechanism may mediate neuronal death in a wide variety of human neurodegenerative diseases.

    Our findings, which are reviewed herein, demonstrate that the types and sequence of changes induced by each of the above methods are identical to those that characterize pcd. In contrast, addition of igf-i, even at physiological concentrations, prevents activation of caspase-3 and neuronal apoptosis. Apoptosis is a word originally introduced by kerr, wyllie, and colleagues for a cell death process they defined in terms of its ultrastructural appearance in nonneuronal cells from various tissues. These results imply a new pathogenetic mechanism for diabetic sensory neuropathy. Check if you have access through your login credentials or your institution.


    Apoptosis in the in Vivo Mammalian Forebrain - ScienceDirect


    Neurobiology of Disease ... Apoptosis in the in Vivo Mammalian Forebrain ... Apoptosis is a word originally introduced by Kerr, Wyllie, and colleagues for a cell  ...

    Apoptosis in Neurobiology

    Neurons Undergo Apoptosis in Animal and Cell Culture Models of ...
    Neurobiology of Disease ... In the current study, hyperglycemia induces apoptotic changes in dorsal root .... D.R. Green, J.C. ReedMitochondria and apoptosis.
    Apoptosis in Neurobiology characteristics that correspond to the classical features of apoptosis, suggesting that these cells may initiate a program of cell death. Check if you have access through your login credentials or your institution. We suggest that oxidative stress may promote the mitochondrial changes in diabetic animals and lead to activation of programmed cell death caspase pathways. Simerly, Annual Review of Neuroscience. C. Similar changes have been reported in neurons in the presence of oxidative stress. Apoptosis is a word originally introduced by kerr, In the absence of such criteria, the kerrwyllie description pertaining to nonneuronal cells has served as a reference standard. ReedMitochondria and apoptosis. This volume allows the uninitiated . Neurobiology of Disease. Recently, several methods have been described for triggering extensive apoptotic neurodegeneration in the developing mammalian brain. Typical apoptotic nuclear and cytoplasmic changes are observed. These results imply a new pathogenetic mechanism for diabetic sensory neuropathy.
  • A potential role for apoptosis in neurodegeneration and Alzheimer's ...


    This confirms that each of these methods produces apoptotic neurodegeneration, and it signifies that our description of this neuronal apoptotic process, which differs in some respects from the kerrwyllie description of nonneuronal apoptosis, can serve as a useful reference standard for recognizing the characteristic changes that check if you have access through your login credentials or your institution. In order to study the neurotoxic effects of high glucose we developed an model using rat dorsal root ganglion neurons. These changes are coupled with activation of caspase-3, dependent on the concentration of glucose. These results imply a new pathogenetic mechanism for diabetic sensory neuropathy. .

    In contrast, addition of igf-i, even at physiological concentrations, prevents activation of caspase-3 and neuronal apoptosis. Our findings, which are reviewed herein, demonstrate that the types and sequence of changes induced by each of the above methods are identical to those that characterize pcd. Check if you have access through your login credentials or your institution. Recent clinical trials indicate that the severity of diabetic neuropathy is correlated with the level of patient glycemic control. Apoptosis is a word originally introduced by kerr, wyllie, and colleagues for a cell death process they defined in terms of its ultrastructural appearance in nonneuronal cells from various tissues.

    Recently, several methods have been described for triggering extensive apoptotic neurodegeneration in the developing mammalian brain. These methods include head trauma or treatment with several types of drugs (nmda antagonists, gaba agonists, or ethanol). We have performed an ultrastructural analysis of the neuronal cell death process triggered in the cerebral cortex and thalamus by these several methods and compared it with physiological cell death (pcd), a prototypic example of neuronal apoptosis that occurs naturally in the developing brain. We suggest that oxidative stress may promote the mitochondrial changes in diabetic animals and lead to activation of programmed cell death caspase pathways. There are very few studies providing detailed ultrastructural criteria for recognizing neuronal apoptosis in the mammalian brain. Typical apoptotic nuclear and cytoplasmic changes are observed. In the absence of such criteria, the kerrwyllie description pertaining to nonneuronal cells has served as a reference standard. Whether the cell death process in neurodegenerative diseases meets ultrastructural criteria for apoptosis has been given very little consideration. In addition mitochondrial changes recently reported to occur as part of the apoptotic cascade, such as ballooning of mitochondria and disruption of the internal cristae, are seen in diabetic dorsal root ganglion neurons and schwann cells. In the current study, hyperglycemia induces apoptotic changes in dorsal root ganglion neurons and schwann cells both in streptozotocin-treated diabetic rats and in rats made acutely hyperglycemic with infused glucose.

    Molecular Neurobiology ... characteristics that correspond to the classical features of apoptosis, suggesting that these cells may initiate a program of cell death.

    Apoptosis in Neural Development and Disease | Annual Review of ...

    Cell death via apoptosis is a prominent feature in mammalian neural development. Recent studies into ... Richard B. Simerly, Annual Review of Neuroscience.
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